Control of microvascular PO2 kinetics following onset of muscle contractions: role for AMPK
نویسندگان
چکیده
Yutaka Kano, David C. Poole, Mizuki Sudo, Toshiro Hirachi, Shinji Miura, and Osamu Ezaki Department of Engineering Science, Bioscience, and Technology Program, University of Electro-Communications, Chofu, Tokyo, Japan; Departments of Anatomy, Physiology and Kinesiology, Kansas State University, Manhattan, Kansas and School of Sports and Health Sciences, University of Exeter, Exeter, United Kingdom; Institute for Physical Activity, Department of Sports and Health Science, Fukuoka University, Fukuoka, Japan; and Department of Nutritional Science, National Institute of Health and Nutrition, Tokyo, Japan
منابع مشابه
Control of microvascular PO₂ kinetics following onset of muscle contractions: role for AMPK.
The microvascular partial pressure of oxygen (Pmv(o(2))) kinetics following the onset of exercise reflects the relationship between muscle O(2) delivery and uptake (Vo(2)). Although AMP-activated protein kinase (AMPK) is known as a regulator of mitochondria and nitric oxide metabolism, it is unclear whether the dynamic balance of O(2) delivery and Vo(2) at exercise onset is dependent on AMPK ac...
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UNLABELLED In rat spinotrapezius muscle, chronic heart failure (CHF) speeds microvascular O2 pressure (pO2; index of O2 delivery-to-O2 uptake) dynamics across the rest-contractions transition [Cardiovasc. Res. 56 (2002) 479]. Due to the mosaic nature of this muscle, the effect of CHF on microvascular pO2 dynamics in different fiber types remains unclear. OBJECTIVE Based upon derangements of e...
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During contractions, regulation of microvascular oxygen partial pressure (Pmv(O2)), which drives blood-myocyte O2 flux, is a function of skeletal muscle fiber type and oxidative capacity and can be altered by exercise training. The kinetics of Pmv(O2) during contractions in predominantly fast-twitch muscles evinces a more rapid fall to far lower levels compared with slow-twitch counterparts. Pe...
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Chronic heart failure (CHF) impairs nitric oxide (NO)-mediated regulation of skeletal muscle O2 delivery-utilization matching such that microvascular oxygenation falls faster (i.e., speeds PO2mv kinetics) during increases in metabolic demand. Conversely, exercise training improves (slows) muscle PO2mv kinetics following contractions onset in healthy young individuals via NO-dependent mechanisms...
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Reactive oxygen species, such as hydrogen peroxide (H(2)O(2)), exert a critical regulatory role on skeletal muscle function. Whether acute increases in H(2)O(2) modulate muscle microvascular O(2) delivery-utilization (Qo(2)/Vo(2)) matching [i.e., microvascular partial pressure of O(2) (Pmv(O(2)))] at rest and following the onset of contractions is unknown. The hypothesis was tested that H(2)O(2...
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